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| Year | Age | Lvl | Lg | Org | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| 2008 | 19 | A- | NYP | BOS | 5 | 3 | .625 | 0 | 15 | 10 | 2 | 0 | 0 | 70.2 | 67 | 32 | 25 | 5 | 17 | 0 | 59 | 0 | 0 | 3.18 | 1.19 | | 2009 | 20 | A | SAL | BOS | 5 | 4 | .556 | 1 | 18 | 12 | 5 | 0 | 0 | 83.0 | 85 | 39 | 31 | 11 | 13 | 1 | 51 | 5 | 0 | 3.36 | 1.18 | | 2009 | 20 | A | SAL | PIT | 4 | 2 | .667 | 0 | 8 | 8 | 0 | 0 | 0 | 43.0 | 42 | 23 | 18 | 3 | 6 | 0 | 23 | 5 | 0 | 3.77 | 1.12 | | 2010 | 21 | A | SAL | PIT | 0 | 4 | .000 | 0 | 8 | 8 | 0 | 0 | 0 | 43.0 | 58 | 30 | 28 | 6 | 8 | 0 | 15 | 5 | 0 | 5.86 | 1.53 | | 2010 | 21 | A+ | FSL | PIT | 2 | 1 | .667 | 0 | 4 | 2 | 0 | 0 | 0 | 14.0 | 16 | 11 | 7 | 1 | 6 | 0 | 10 | 1 | 0 | 4.50 | 1.57 | | 2012 | 23 | A+ | FSL | PIT | 2 | 2 | .500 | 0 | 10 | 9 | 1 | 0 | 0 | 45.1 | 47 | 16 | 15 | 5 | 8 | 0 | 25 | 6 | 0 | 2.98 | 1.21 | | 2012 | 23 | AA | EAS | PIT | 2 | 2 | .500 | 2 | 23 | 0 | 10 | 0 | 0 | 42.1 | 50 | 23 | 21 | 5 | 15 | 0 | 33 | 3 | 0 | 4.46 | 1.54 | | 2013 | 24 | A+ | CAL | SF | 1 | 0 | 1.000 | 9 | 20 | 0 | 18 | 0 | 0 | 21.0 | 10 | 2 | 2 | 1 | 5 | 1 | 23 | 1 | 0 | 0.86 | 0.71 | | 2014 | 25 | A+ | CAL | SF | 0 | 0 | --- | 0 | 3 | 0 | 0 | 0 | 0 | 3.0 | 2 | 1 | 1 | 0 | 0 | 0 | 7 | 0 | 0 | 3.00 | 0.67 | | 2014 | 25 | AA | EAS | SF | 1 | 1 | .500 | 11 | 38 | 0 | 27 | 0 | 0 | 35.2 | 25 | 10 | 8 | 3 | 4 | 0 | 48 | 0 | 0 | 2.02 | 0.81 | | 2014 | 25 | MLB | NL | SF | 1 | 0 | 1.000 | 1 | 9 | 0 | 5 | 0 | 0 | 7.0 | 5 | 0 | 0 | 0 | 0 | 0 | 9 | 0 | 0 | 0.00 | 0.71 | | 2015 | 26 | AAA | PCL | SF | 1 | 1 | .500 | 5 | 15 | 0 | 10 | 0 | 0 | 21.1 | 14 | 5 | 4 | 0 | 3 | 0 | 25 | 1 | 0 | 1.69 | 0.80 | | 2015 | 26 | MLB | NL | SF | 3 | 3 | .500 | 0 | 55 | 0 | 11 | 0 | 0 | 51.1 | 34 | 14 | 14 | 4 | 10 | 1 | 50 | 2 | 2 | 2.45 | 0.86 | | 2016 | 27 | MLB | NL | SF | 3 | 3 | .500 | 3 | 72 | 0 | 14 | 0 | 0 | 61.0 | 50 | 21 | 21 | 4 | 19 | 3 | 57 | 2 | 2 | 3.10 | 1.13 | | 2017 | 28 | MLB | NL | SF | 4 | 3 | .571 | 1 | 68 | 0 | 17 | 0 | 0 | 61.1 | 59 | 20 | 18 | 4 | 29 | 4 | 58 | 2 | 5 | 2.64 | 1.43 | | 2018 | 29 | R | AZL | | 0 | 0 | --- | 0 | 1 | 1 | 0 | 0 | 0 | 1.0 | 2 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0.00 | 2.00 | | 2018 | 29 | A+ | CAL | | 0 | 0 | --- | 0 | 1 | 0 | 0 | 0 | 0 | 0.2 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 13.50 | 3.00 | | 2018 | 29 | AAA | PCL | | 0 | 0 | --- | 0 | 4 | 0 | 0 | 0 | 0 | 4.0 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 0 | 0 | 0.00 | 0.00 | | 2018 | 29 | MLB | NL | SF | 3 | 5 | .375 | 14 | 49 | 0 | 35 | 0 | 0 | 45.1 | 43 | 25 | 20 | 5 | 21 | 2 | 37 | 1 | 3 | 3.97 | 1.41 | | 2019 | 30 | AAA | PCL | | 0 | 0 | --- | 0 | 3 | 0 | 0 | 0 | 0 | 3.0 | 2 | 1 | 1 | 1 | 1 | 0 | 4 | 0 | 0 | 3.00 | 1.00 | | 2019 | 30 | MLB | AL | SEA | 0 | 1 | .000 | 2 | 4 | 0 | 2 | 0 | 0 | 3.1 | 2 | 3 | 3 | 1 | 0 | 0 | 3 | 1 | 0 | 8.10 | 0.60 | | 2019 | 30 | MLB | NL | WAS | 2 | 0 | 1.000 | 0 | 24 | 0 | 1 | 0 | 0 | 21.0 | 20 | 12 | 12 | 5 | 8 | 0 | 15 | 2 | 2 | 5.14 | 1.33 | | 2019 | 30 | MLB | | TOT | 2 | 1 | .667 | 2 | 28 | 0 | 3 | 0 | 0 | 24.1 | 22 | 15 | 15 | 6 | 8 | 0 | 18 | 3 | 2 | 5.55 | 1.23 | | 2020 | 31 | MLB | NL | NYN | 0 | 1 | .000 | 0 | 4 | 0 | 2 | 0 | 0 | 3.1 | 5 | 4 | 3 | 0 | 1 | 0 | 4 | 0 | 0 | 8.10 | 1.80 | | 2021 | 32 | MLB | AL | TB | 0 | 0 | --- | 0 | 13 | 0 | 7 | 0 | 0 | 16.0 | 14 | 4 | 3 | 1 | 6 | 0 | 16 | 0 | 2 | 1.69 | 1.25 | | 2021 | 32 | MLB | AL | LAA | 0 | 0 | --- | 0 | 9 | 0 | 2 | 0 | 0 | 6.1 | 11 | 9 | 7 | 3 | 4 | 0 | 4 | 0 | 0 | 9.95 | 2.37 | | 2021 | 32 | MLB | NL | MIL | 3 | 2 | .600 | 0 | 35 | 0 | 10 | 0 | 0 | 36.1 | 21 | 8 | 7 | 4 | 12 | 0 | 38 | 2 | 3 | 1.73 | 0.91 | | 2021 | 32 | MLB | AL | TOT | 0 | 0 | --- | 0 | 22 | 0 | 9 | 0 | 0 | 22.1 | 25 | 13 | 10 | 4 | 10 | 0 | 20 | 0 | 2 | 4.03 | 1.57 | | 2021 | 32 | MLB | | TOT | 3 | 2 | .600 | 0 | 57 | 0 | 19 | 0 | 0 | 58.2 | 46 | 21 | 17 | 8 | 22 | 0 | 58 | 2 | 5 | 2.61 | 1.16 | | 2022 | 33 | MLB | NL | CIN | 3 | 3 | .500 | 7 | 66 | 0 | 35 | 0 | 0 | 62.1 | 61 | 37 | 34 | 8 | 33 | 1 | 60 | 7 | 5 | 4.91 | 1.51 | | 2024 | 35 | MLB | AL | LAA | 3 | 2 | .600 | 1 | 72 | 0 | 10 | 0 | 0 | 73.1 | 56 | 31 | 27 | 10 | 24 | 1 | 57 | 2 | 7 | 3.31 | 1.09 | | 2025 | 36 | MLB | AL | LAA | 1 | 2 | .333 | 1 | 19 | 0 | 6 | 0 | 0 | 22.0 | 17 | 9 | 8 | 2 | 10 | 2 | 14 | 0 | 1 | 3.27 | 1.23 | | Totals | | | | | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| Minors | Minors | 23 | 20 | .535 | 28 | 171 | 50 | 73 | 0 | 0 | 431.0 | 421 | 195 | 162 | 42 | 87 | 2 | 333 | 27 | 0 | 3.38 | 1.18 | | Career | SF | 14 | 14 | .500 | 19 | 253 | 0 | 82 | 0 | 0 | 226.0 | 191 | 80 | 73 | 17 | 79 | 10 | 211 | 7 | 12 | 2.91 | 1.19 | | Career | SEA | 0 | 1 | .000 | 2 | 4 | 0 | 2 | 0 | 0 | 3.1 | 2 | 3 | 3 | 1 | 0 | 0 | 3 | 1 | 0 | 8.10 | 0.60 | | Career | WAS | 2 | 0 | 1.000 | 0 | 24 | 0 | 1 | 0 | 0 | 21.0 | 20 | 12 | 12 | 5 | 8 | 0 | 15 | 2 | 2 | 5.14 | 1.33 | | Career | NYN | 0 | 1 | .000 | 0 | 4 | 0 | 2 | 0 | 0 | 3.1 | 5 | 4 | 3 | 0 | 1 | 0 | 4 | 0 | 0 | 8.10 | 1.80 | | Career | TB | 0 | 0 | --- | 0 | 13 | 0 | 7 | 0 | 0 | 16.0 | 14 | 4 | 3 | 1 | 6 | 0 | 16 | 0 | 2 | 1.69 | 1.25 | | Career | LAA | 4 | 4 | .500 | 2 | 100 | 0 | 18 | 0 | 0 | 101.2 | 84 | 49 | 42 | 15 | 38 | 3 | 75 | 2 | 8 | 3.72 | 1.20 | | Career | MIL | 3 | 2 | .600 | 0 | 35 | 0 | 10 | 0 | 0 | 36.1 | 21 | 8 | 7 | 4 | 12 | 0 | 38 | 2 | 3 | 1.73 | 0.91 | | Career | CIN | 3 | 3 | .500 | 7 | 66 | 0 | 35 | 0 | 0 | 62.1 | 61 | 37 | 34 | 8 | 33 | 1 | 60 | 7 | 5 | 4.91 | 1.51 | | Career | Majors | 26 | 25 | .510 | 30 | 499 | 0 | 157 | 0 | 0 | 470.0 | 398 | 197 | 177 | 51 | 177 | 14 | 422 | 21 | 32 | 3.39 | 1.22 |
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| Year | Age | Lvl | Lg | Org | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| 2014 | 25 | MLB | NL | SF | | | | | | | | | | 2.2 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0.00 | 0.75 | | 2014 | 25 | MLB | NL | SF | | | | | | | | | | 4.1 | 3 | 0 | 0 | 0 | 0 | 0 | 7 | 0 | 0 | 0.00 | 0.69 | | 2015 | 26 | MLB | NL | SF | | | | | | | | | | 18.1 | 12 | 5 | 5 | 1 | 4 | 1 | 11 | 0 | 2 | 2.45 | 0.87 | | 2015 | 26 | MLB | NL | SF | | | | | | | | | | 33.0 | 22 | 9 | 9 | 3 | 6 | 0 | 39 | 2 | 0 | 2.45 | 0.85 | | 2016 | 27 | MLB | NL | SF | | | | | | | | | | 18.0 | 20 | 6 | 6 | 2 | 8 | 3 | 11 | 1 | 1 | 3.00 | 1.56 | | 2016 | 27 | MLB | NL | SF | | | | | | | | | | 43.0 | 30 | 15 | 15 | 2 | 11 | 0 | 46 | 1 | 1 | 3.14 | 0.95 | | 2017 | 28 | MLB | NL | SF | | | | | | | | | | 21.1 | 30 | 9 | 8 | 1 | 16 | 4 | 16 | 1 | 2 | 3.38 | 2.16 | | 2017 | 28 | MLB | NL | SF | | | | | | | | | | 40.0 | 29 | 11 | 10 | 3 | 13 | 0 | 42 | 1 | 3 | 2.25 | 1.05 | | 2018 | 29 | MLB | NL | SF | | | | | | | | | | 23.2 | 16 | 11 | 8 | 2 | 11 | 1 | 21 | 0 | 1 | 3.04 | 1.14 | | 2018 | 29 | MLB | NL | SF | | | | | | | | | | 21.2 | 27 | 14 | 12 | 3 | 10 | 1 | 16 | 1 | 2 | 4.98 | 1.71 | | 2019 | 30 | MLB | | TOT | | | | | | | | | | 9.0 | 13 | 8 | 8 | 5 | 5 | 0 | 2 | 1 | 0 | 8.00 | 2.00 | | 2019 | 30 | MLB | | TOT | | | | | | | | | | 15.1 | 9 | 7 | 7 | 1 | 3 | 0 | 16 | 2 | 2 | 4.11 | 0.78 | | 2020 | 31 | MLB | NL | NYN | | | | | | | | | | 2.0 | 1 | 1 | 1 | 0 | 1 | 0 | 2 | 0 | 0 | 4.50 | 1.00 | | 2020 | 31 | MLB | NL | NYN | | | | | | | | | | 1.1 | 4 | 3 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 13.50 | 3.00 | | 2021 | 32 | MLB | | TOT | | | | | | | | | | 20.0 | 19 | 9 | 7 | 1 | 8 | 0 | 10 | 0 | 2 | 3.15 | 1.35 | | 2021 | 32 | MLB | | TOT | | | | | | | | | | 38.2 | 27 | 12 | 10 | 7 | 14 | 0 | 48 | 2 | 3 | 2.33 | 1.06 | | 2022 | 33 | MLB | NL | CIN | | | | | | | | | | 27.1 | 31 | 17 | 16 | 5 | 12 | 1 | 35 | 1 | 3 | 5.27 | 1.57 | | 2022 | 33 | MLB | NL | CIN | | | | | | | | | | 35.0 | 30 | 20 | 18 | 3 | 21 | 0 | 25 | 6 | 2 | 4.63 | 1.46 | | 2024 | 35 | MLB | AL | LAA | | | | | | | | | | 25.2 | 19 | 10 | 10 | 3 | 14 | 0 | 17 | 1 | 3 | 3.51 | 1.29 | | 2024 | 35 | MLB | AL | LAA | | | | | | | | | | 47.2 | 37 | 21 | 17 | 7 | 10 | 1 | 40 | 1 | 4 | 3.21 | 0.99 | | 2025 | 36 | MLB | AL | LAA | | | | | | | | | | 10.0 | 7 | 3 | 3 | 1 | 5 | 1 | 5 | 0 | 0 | 2.70 | 1.20 | | 2025 | 36 | MLB | AL | LAA | | | | | | | | | | 12.0 | 10 | 6 | 5 | 1 | 5 | 1 | 9 | 0 | 1 | 3.75 | 1.25 | | Totals | | | | | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| Career | vs LH | | | | | | | | | | 178.0 | 170 | 79 | 72 | 21 | 84 | 11 | 132 | 5 | 14 | 3.64 | 1.43 | | Career | vs RH | | | | | | | | | | 292.0 | 228 | 118 | 105 | 30 | 93 | 3 | 290 | 16 | 18 | 3.24 | 1.10 |
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| Year | Age | Lvl | Lg | Org | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| 2012 | 23 | AA | EAS | PIT | 23 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2015 | 26 | AAA | PCL | SF | 15 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2015 | 26 | MLB | NL | SF | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2021 | 32 | MLB | NL | MIL | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | Totals | | | | | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| Minors | Minors | 38 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | Career | SF | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | Career | MIL | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | Career | Majors | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 |
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| Year | Age | Lvl | Lg | Org | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| 2015 | 26 | MLB | NL | SF | | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | --- | --- | --- | --- | | 2015 | 26 | MLB | NL | SF | | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2021 | 32 | MLB | NL | MIL | | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2021 | 32 | MLB | NL | MIL | | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | Totals | | | | | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| Career | vs LH | | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | Career | vs RH | | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 |
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