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| Year | Age | Lvl | Lg | Org | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| 2012 | 20 | R | GCL | STL | 0 | 0 | --- | 0 | 3 | 2 | 0 | 0 | 0 | 5.0 | 4 | 1 | 1 | 1 | 0 | 0 | 7 | 0 | 0 | 1.80 | 0.80 | | 2012 | 20 | A+ | FSL | STL | 0 | 0 | --- | 0 | 4 | 0 | 2 | 0 | 0 | 8.0 | 1 | 0 | 0 | 0 | 1 | 0 | 16 | 0 | 0 | 0.00 | 0.25 | | 2012 | 20 | AA | TEX | STL | 0 | 0 | --- | 0 | 4 | 0 | 0 | 0 | 0 | 8.0 | 3 | 1 | 1 | 0 | 3 | 0 | 17 | 0 | 0 | 1.13 | 0.75 | | 2013 | 21 | AAA | PCL | STL | 5 | 3 | .625 | 0 | 15 | 15 | 0 | 0 | 0 | 85.0 | 65 | 26 | 25 | 9 | 19 | 0 | 73 | 0 | 0 | 2.65 | 0.99 | | 2013 | 21 | MLB | NL | STL | 4 | 1 | .800 | 0 | 15 | 9 | 2 | 0 | 0 | 64.2 | 52 | 20 | 20 | 5 | 19 | 0 | 65 | 0 | 6 | 2.78 | 1.10 | | 2014 | 22 | AA | TEX | STL | 0 | 0 | --- | 0 | 1 | 1 | 0 | 0 | 0 | 2.0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0.00 | 1.00 | | 2014 | 22 | MLB | NL | STL | 5 | 6 | .455 | 0 | 19 | 19 | 0 | 0 | 0 | 107.0 | 95 | 41 | 38 | 6 | 33 | 0 | 94 | 5 | 10 | 3.20 | 1.20 | | 2015 | 23 | MLB | NL | STL | 17 | 7 | .708 | 0 | 30 | 30 | 0 | 0 | 0 | 181.1 | 162 | 74 | 68 | 19 | 58 | 4 | 153 | 6 | 9 | 3.38 | 1.21 | | 2016 | 24 | MLB | NL | STL | 7 | 7 | .500 | 0 | 27 | 24 | 1 | 0 | 0 | 138.0 | 159 | 86 | 78 | 15 | 45 | 6 | 114 | 1 | 11 | 5.09 | 1.48 | | 2017 | 25 | MLB | NL | STL | 12 | 9 | .571 | 0 | 30 | 30 | 0 | 1 | 1 | 165.2 | 170 | 82 | 76 | 17 | 55 | 3 | 158 | 3 | 18 | 4.13 | 1.36 | | 2018 | 26 | A+ | FSL | | 0 | 0 | --- | 0 | 2 | 2 | 0 | 0 | 0 | 4.0 | 2 | 3 | 3 | 0 | 2 | 0 | 5 | 0 | 0 | 6.75 | 1.00 | | 2018 | 26 | AA | TEX | | 0 | 1 | .000 | 0 | 1 | 1 | 0 | 0 | 0 | 2.1 | 6 | 5 | 3 | 1 | 1 | 0 | 3 | 0 | 0 | 11.57 | 3.00 | | 2018 | 26 | MLB | NL | STL | 8 | 2 | .800 | 0 | 15 | 15 | 0 | 0 | 0 | 84.1 | 68 | 36 | 30 | 9 | 36 | 0 | 71 | 2 | 4 | 3.20 | 1.23 | | 2019 | 27 | MLB | NL | STL | 6 | 7 | .462 | 0 | 29 | 24 | 0 | 0 | 0 | 126.2 | 143 | 71 | 67 | 26 | 54 | 4 | 104 | 3 | 15 | 4.76 | 1.56 | | 2020 | 28 | MLB | NL | NYN | 1 | 4 | .200 | 0 | 8 | 7 | 0 | 0 | 0 | 34.0 | 46 | 26 | 25 | 9 | 7 | 0 | 37 | 2 | 1 | 6.62 | 1.56 | | 2021 | 29 | MLB | AL | TB | 3 | 5 | .375 | 0 | 29 | 23 | 1 | 0 | 0 | 124.2 | 132 | 73 | 70 | 23 | 31 | 0 | 121 | 4 | 10 | 5.05 | 1.31 | | 2022 | 30 | MLB | AL | BOS | 11 | 2 | .846 | 0 | 23 | 23 | 0 | 1 | 1 | 127.1 | 111 | 49 | 47 | 18 | 31 | 0 | 104 | 4 | 12 | 3.32 | 1.12 | | 2023 | 31 | MLB | NL | SD | 14 | 4 | .778 | 0 | 24 | 24 | 0 | 0 | 0 | 134.1 | 113 | 49 | 48 | 15 | 43 | 0 | 124 | 3 | 5 | 3.22 | 1.16 | | 2024 | 32 | MLB | AL | KC | 13 | 8 | .619 | 0 | 29 | 29 | 0 | 0 | 0 | 166.2 | 154 | 65 | 62 | 17 | 45 | 1 | 145 | 5 | 17 | 3.35 | 1.19 | | 2025 | 33 | MLB | AL | KC | 10 | 13 | .435 | 0 | 31 | 31 | 0 | 0 | 0 | 172.2 | 166 | 74 | 74 | 15 | 45 | 0 | 126 | 4 | 18 | 3.86 | 1.22 | | Totals | | | | | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| Minors | Minors | 5 | 4 | .556 | 0 | 30 | 21 | 2 | 0 | 0 | 114.1 | 82 | 36 | 33 | 11 | 27 | 0 | 122 | 0 | 0 | 2.60 | 0.95 | | Career | STL | 59 | 39 | .602 | 0 | 165 | 151 | 3 | 1 | 1 | 867.2 | 849 | 410 | 377 | 97 | 300 | 17 | 759 | 20 | 73 | 3.91 | 1.32 | | Career | NYN | 1 | 4 | .200 | 0 | 8 | 7 | 0 | 0 | 0 | 34.0 | 46 | 26 | 25 | 9 | 7 | 0 | 37 | 2 | 1 | 6.62 | 1.56 | | Career | TB | 3 | 5 | .375 | 0 | 29 | 23 | 1 | 0 | 0 | 124.2 | 132 | 73 | 70 | 23 | 31 | 0 | 121 | 4 | 10 | 5.05 | 1.31 | | Career | BOS | 11 | 2 | .846 | 0 | 23 | 23 | 0 | 1 | 1 | 127.1 | 111 | 49 | 47 | 18 | 31 | 0 | 104 | 4 | 12 | 3.32 | 1.12 | | Career | SD | 14 | 4 | .778 | 0 | 24 | 24 | 0 | 0 | 0 | 134.1 | 113 | 49 | 48 | 15 | 43 | 0 | 124 | 3 | 5 | 3.22 | 1.16 | | Career | KC | 23 | 21 | .523 | 0 | 60 | 60 | 0 | 0 | 0 | 339.1 | 320 | 139 | 136 | 32 | 90 | 1 | 271 | 9 | 35 | 3.61 | 1.21 | | Career | Majors | 111 | 75 | .597 | 0 | 309 | 288 | 4 | 2 | 2 | 1627.1 | 1571 | 746 | 703 | 194 | 502 | 18 | 1416 | 42 | 136 | 3.89 | 1.27 |
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| Year | Age | Lvl | Lg | Org | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| 2013 | 21 | MLB | NL | STL | | | | | | | | | | 32.1 | 23 | 6 | 6 | 1 | 9 | 0 | 28 | 0 | 3 | 1.67 | 0.99 | | 2013 | 21 | MLB | NL | STL | | | | | | | | | | 32.1 | 29 | 14 | 14 | 4 | 10 | 0 | 37 | 0 | 3 | 3.90 | 1.21 | | 2014 | 22 | MLB | NL | STL | | | | | | | | | | 51.2 | 44 | 20 | 18 | 1 | 19 | 0 | 40 | 1 | 3 | 3.14 | 1.22 | | 2014 | 22 | MLB | NL | STL | | | | | | | | | | 55.1 | 51 | 21 | 20 | 5 | 14 | 0 | 54 | 4 | 7 | 3.25 | 1.17 | | 2015 | 23 | MLB | NL | STL | | | | | | | | | | 81.0 | 65 | 30 | 27 | 6 | 27 | 3 | 66 | 3 | 3 | 3.00 | 1.14 | | 2015 | 23 | MLB | NL | STL | | | | | | | | | | 100.1 | 97 | 44 | 41 | 13 | 31 | 1 | 87 | 3 | 6 | 3.68 | 1.28 | | 2016 | 24 | MLB | NL | STL | | | | | | | | | | 60.1 | 62 | 32 | 29 | 5 | 18 | 2 | 47 | 1 | 2 | 4.33 | 1.33 | | 2016 | 24 | MLB | NL | STL | | | | | | | | | | 77.2 | 97 | 54 | 49 | 10 | 27 | 4 | 67 | 0 | 9 | 5.68 | 1.60 | | 2017 | 25 | MLB | NL | STL | | | | | | | | | | 74.0 | 72 | 41 | 38 | 7 | 34 | 2 | 64 | 2 | 6 | 4.62 | 1.43 | | 2017 | 25 | MLB | NL | STL | | | | | | | | | | 91.2 | 98 | 41 | 38 | 10 | 21 | 1 | 94 | 1 | 12 | 3.73 | 1.30 | | 2018 | 26 | MLB | NL | STL | | | | | | | | | | 41.2 | 34 | 15 | 12 | 3 | 13 | 0 | 37 | 1 | 0 | 2.59 | 1.13 | | 2018 | 26 | MLB | NL | STL | | | | | | | | | | 42.2 | 34 | 21 | 18 | 6 | 23 | 0 | 34 | 1 | 4 | 3.80 | 1.34 | | 2019 | 27 | MLB | NL | STL | | | | | | | | | | 49.2 | 49 | 27 | 25 | 8 | 25 | 3 | 40 | 3 | 7 | 4.53 | 1.49 | | 2019 | 27 | MLB | NL | STL | | | | | | | | | | 77.0 | 94 | 44 | 42 | 18 | 29 | 1 | 64 | 0 | 8 | 4.91 | 1.60 | | 2020 | 28 | MLB | NL | NYN | | | | | | | | | | 16.1 | 19 | 7 | 7 | 3 | 5 | 0 | 20 | 1 | 0 | 3.86 | 1.47 | | 2020 | 28 | MLB | NL | NYN | | | | | | | | | | 17.2 | 27 | 19 | 18 | 6 | 2 | 0 | 17 | 1 | 1 | 9.17 | 1.64 | | 2021 | 29 | MLB | AL | TB | | | | | | | | | | 50.0 | 45 | 26 | 26 | 8 | 13 | 0 | 42 | 2 | 6 | 4.68 | 1.16 | | 2021 | 29 | MLB | AL | TB | | | | | | | | | | 74.2 | 87 | 47 | 44 | 15 | 18 | 0 | 79 | 2 | 4 | 5.30 | 1.41 | | 2022 | 30 | MLB | AL | BOS | | | | | | | | | | 55.2 | 37 | 19 | 19 | 8 | 15 | 0 | 50 | 2 | 4 | 3.07 | 0.93 | | 2022 | 30 | MLB | AL | BOS | | | | | | | | | | 71.2 | 74 | 30 | 28 | 10 | 16 | 0 | 54 | 2 | 8 | 3.52 | 1.26 | | 2023 | 31 | MLB | NL | SD | | | | | | | | | | 62.0 | 55 | 21 | 21 | 6 | 23 | 0 | 60 | 1 | 3 | 3.05 | 1.26 | | 2023 | 31 | MLB | NL | SD | | | | | | | | | | 72.1 | 58 | 28 | 27 | 9 | 20 | 0 | 64 | 2 | 2 | 3.36 | 1.08 | | 2024 | 32 | MLB | AL | KC | | | | | | | | | | 88.0 | 80 | 31 | 30 | 9 | 21 | 1 | 78 | 1 | 9 | 3.07 | 1.15 | | 2024 | 32 | MLB | AL | KC | | | | | | | | | | 78.2 | 74 | 34 | 32 | 8 | 24 | 0 | 67 | 4 | 8 | 3.66 | 1.25 | | 2025 | 33 | MLB | AL | KC | | | | | | | | | | 90.1 | 84 | 37 | 37 | 5 | 23 | 0 | 63 | 2 | 7 | 3.69 | 1.18 | | 2025 | 33 | MLB | AL | KC | | | | | | | | | | 82.1 | 82 | 37 | 37 | 10 | 22 | 0 | 63 | 2 | 11 | 4.04 | 1.26 | | Totals | | | | | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| Career | vs LH | | | | | | | | | | 753.0 | 669 | 312 | 295 | 70 | 245 | 11 | 635 | 20 | 53 | 3.53 | 1.21 | | Career | vs RH | | | | | | | | | | 874.1 | 902 | 434 | 408 | 124 | 257 | 7 | 781 | 22 | 83 | 4.20 | 1.33 |
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| Year | Age | Lvl | Lg | Org | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| 2012 | 20 | AA | TEX | STL | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2013 | 21 | AAA | PCL | STL | 15 | 10 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 1 | 0 | 0 | 0 | .100 | .100 | .100 | .200 | | 2013 | 21 | MLB | NL | STL | 10 | 21 | 0 | 3 | 0 | 0 | 0 | 3 | 0 | 0 | 10 | 0 | 0 | 1 | 0 | 0 | 0 | .143 | .143 | .143 | .286 | | 2014 | 22 | AA | TEX | STL | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | --- | 1.000 | --- | 1.000 | | 2014 | 22 | MLB | NL | STL | 17 | 29 | 1 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 18 | 0 | 0 | 3 | 0 | 0 | 0 | .034 | .034 | .034 | .069 | | 2015 | 23 | MLB | NL | STL | 27 | 52 | 5 | 8 | 1 | 0 | 0 | 4 | 4 | 0 | 20 | 1 | 0 | 6 | 0 | 0 | 0 | .154 | .214 | .173 | .387 | | 2016 | 24 | MLB | NL | STL | 23 | 39 | 1 | 1 | 0 | 0 | 0 | 0 | 3 | 0 | 22 | 0 | 0 | 3 | 0 | 0 | 1 | .026 | .095 | .026 | .121 | | 2017 | 25 | MLB | NL | STL | 28 | 46 | 3 | 2 | 0 | 0 | 0 | 3 | 1 | 0 | 22 | 0 | 0 | 7 | 1 | 0 | 2 | .043 | .063 | .043 | .106 | | 2018 | 26 | MLB | NL | STL | 15 | 25 | 3 | 2 | 0 | 0 | 0 | 1 | 1 | 0 | 9 | 0 | 0 | 6 | 0 | 0 | 0 | .080 | .115 | .080 | .195 | | 2019 | 27 | MLB | NL | STL | 22 | 36 | 3 | 6 | 1 | 0 | 0 | 3 | 0 | 0 | 21 | 0 | 0 | 3 | 0 | 0 | 0 | .167 | .167 | .194 | .361 | | 2021 | 29 | MLB | AL | TB | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | Totals | | | | | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| Minors | Minors | 20 | 11 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 4 | 0 | 0 | 1 | 0 | 0 | 0 | .091 | .167 | .091 | .258 | | Career | STL | 142 | 248 | 16 | 23 | 2 | 0 | 0 | 16 | 9 | 0 | 122 | 1 | 0 | 29 | 1 | 0 | 3 | .093 | .124 | .101 | .225 | | Career | TB | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | Career | Majors | 145 | 251 | 16 | 23 | 2 | 0 | 0 | 16 | 9 | 0 | 125 | 1 | 0 | 29 | 1 | 0 | 3 | .092 | .123 | .100 | .222 |
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| Year | Age | Lvl | Lg | Org | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| 2013 | 21 | MLB | NL | STL | | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | .250 | .250 | .250 | .500 | | 2013 | 21 | MLB | NL | STL | | 17 | 0 | 2 | 0 | 0 | 0 | 3 | 0 | 0 | 7 | 0 | 0 | 1 | 0 | 0 | 0 | .118 | .118 | .118 | .235 | | 2014 | 22 | MLB | NL | STL | | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 0 | 0 | 2 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2014 | 22 | MLB | NL | STL | | 20 | 1 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 11 | 0 | 0 | 1 | 0 | 0 | 0 | .050 | .050 | .050 | .100 | | 2015 | 23 | MLB | NL | STL | | 12 | 2 | 2 | 0 | 0 | 0 | 2 | 2 | 0 | 4 | 0 | 0 | 3 | 0 | 0 | 0 | .167 | .286 | .167 | .452 | | 2015 | 23 | MLB | NL | STL | | 40 | 3 | 6 | 1 | 0 | 0 | 2 | 2 | 0 | 16 | 1 | 0 | 3 | 0 | 0 | 0 | .150 | .190 | .175 | .365 | | 2016 | 24 | MLB | NL | STL | | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 3 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2016 | 24 | MLB | NL | STL | | 32 | 1 | 1 | 0 | 0 | 0 | 0 | 3 | 0 | 19 | 0 | 0 | 0 | 0 | 0 | 1 | .031 | .114 | .031 | .146 | | 2017 | 25 | MLB | NL | STL | | 11 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 5 | 0 | 0 | 0 | 1 | 0 | 1 | .091 | .083 | .091 | .174 | | 2017 | 25 | MLB | NL | STL | | 35 | 2 | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 17 | 0 | 0 | 7 | 0 | 0 | 1 | .029 | .056 | .029 | .084 | | 2018 | 26 | MLB | NL | STL | | 6 | 1 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 3 | 0 | 0 | 0 | .333 | .333 | .333 | .667 | | 2018 | 26 | MLB | NL | STL | | 19 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 8 | 0 | 0 | 3 | 0 | 0 | 0 | .000 | .050 | .000 | .050 | | 2019 | 27 | MLB | NL | STL | | 5 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | .200 | .200 | .200 | .400 | | 2019 | 27 | MLB | NL | STL | | 31 | 3 | 5 | 1 | 0 | 0 | 2 | 0 | 0 | 18 | 0 | 0 | 3 | 0 | 0 | 0 | .161 | .161 | .194 | .355 | | 2021 | 29 | MLB | AL | TB | | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | --- | --- | --- | --- | | 2021 | 29 | MLB | AL | TB | | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | Totals | | | | | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| Career | vs LH | | 54 | 4 | 7 | 0 | 0 | 0 | 5 | 2 | 0 | 26 | 0 | 0 | 11 | 1 | 0 | 1 | .130 | .158 | .130 | .288 | | Career | vs RH | | 197 | 12 | 16 | 2 | 0 | 0 | 11 | 7 | 0 | 99 | 1 | 0 | 18 | 0 | 0 | 2 | .081 | .113 | .091 | .204 |
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