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| Year | Age | Lvl | Lg | Org | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| 2012 | 21 | R | APP | MIN | 2 | 1 | .667 | 0 | 6 | 6 | 0 | 0 | 0 | 30.0 | 20 | 7 | 6 | 2 | 5 | 0 | 39 | 3 | 0 | 1.80 | 0.83 | | 2012 | 21 | A | MWL | MIN | 2 | 2 | .500 | 0 | 9 | 4 | 0 | 0 | 0 | 33.1 | 33 | 18 | 10 | 5 | 12 | 0 | 35 | 2 | 0 | 2.70 | 1.35 | | 2013 | 22 | A | MWL | MIN | 0 | 1 | .000 | 0 | 3 | 3 | 0 | 0 | 0 | 10.0 | 14 | 12 | 8 | 1 | 4 | 0 | 10 | 0 | 0 | 7.20 | 1.80 | | 2013 | 22 | A+ | FSL | MIN | 11 | 6 | .647 | 0 | 22 | 21 | 0 | 3 | 2 | 130.1 | 119 | 46 | 37 | 5 | 32 | 0 | 83 | 9 | 0 | 2.55 | 1.16 | | 2014 | 23 | AA | EAS | MIN | 11 | 6 | .647 | 0 | 24 | 24 | 0 | 1 | 0 | 145.0 | 150 | 63 | 53 | 4 | 37 | 0 | 113 | 6 | 0 | 3.29 | 1.29 | | 2015 | 24 | AAA | INT | MIN | 11 | 12 | .478 | 0 | 28 | 27 | 1 | 2 | 0 | 174.0 | 190 | 83 | 77 | 9 | 44 | 2 | 126 | 4 | 0 | 3.98 | 1.34 | | 2016 | 25 | AAA | INT | MIN | 0 | 1 | .000 | 0 | 7 | 2 | 1 | 0 | 0 | 18.0 | 24 | 15 | 9 | 1 | 6 | 0 | 15 | 0 | 0 | 4.50 | 1.67 | | 2016 | 25 | MLB | AL | MIN | 3 | 1 | .750 | 0 | 57 | 0 | 8 | 0 | 0 | 61.1 | 63 | 29 | 27 | 7 | 16 | 3 | 64 | 5 | 9 | 3.96 | 1.29 | | 2017 | 26 | MLB | AL | MIN | 7 | 3 | .700 | 0 | 69 | 0 | 7 | 0 | 0 | 55.2 | 52 | 20 | 19 | 6 | 21 | 5 | 49 | 3 | 4 | 3.07 | 1.31 | | 2018 | 27 | MLB | AL | MIN | 1 | 2 | .333 | 2 | 72 | 0 | 6 | 0 | 0 | 68.1 | 49 | 20 | 20 | 3 | 16 | 3 | 75 | 2 | 6 | 2.63 | 0.95 | | 2019 | 28 | MLB | AL | MIN | 2 | 4 | .333 | 30 | 60 | 0 | 36 | 0 | 0 | 69.0 | 58 | 20 | 20 | 8 | 11 | 2 | 90 | 6 | 6 | 2.61 | 1.00 | | 2020 | 29 | MLB | AL | MIN | 2 | 4 | .333 | 9 | 21 | 0 | 16 | 0 | 0 | 20.0 | 26 | 14 | 9 | 2 | 4 | 0 | 24 | 1 | 1 | 4.05 | 1.50 | | 2021 | 30 | MLB | AL | MIN | 2 | 4 | .333 | 9 | 39 | 0 | 15 | 0 | 0 | 40.1 | 38 | 18 | 15 | 4 | 8 | 2 | 59 | 0 | 5 | 3.35 | 1.14 | | 2022 | 31 | MLB | NL | SD | 1 | 5 | .167 | 28 | 42 | 0 | 35 | 0 | 0 | 41.1 | 37 | 22 | 20 | 1 | 9 | 1 | 48 | 8 | 4 | 4.35 | 1.11 | | 2022 | 31 | MLB | NL | MIL | 3 | 3 | .500 | 3 | 24 | 0 | 5 | 0 | 0 | 23.0 | 20 | 16 | 14 | 6 | 10 | 1 | 36 | 3 | 1 | 5.48 | 1.30 | | 2022 | 31 | MLB | NL | TOT | 4 | 8 | .333 | 31 | 66 | 0 | 40 | 0 | 0 | 64.1 | 57 | 38 | 34 | 7 | 19 | 2 | 84 | 11 | 5 | 4.76 | 1.18 | | 2023 | 32 | MLB | NL | SF | 6 | 4 | .600 | 2 | 60 | 0 | 12 | 0 | 0 | 51.2 | 39 | 27 | 22 | 6 | 25 | 3 | 64 | 3 | 5 | 3.83 | 1.24 | | 2024 | 33 | MLB | NL | SF | 1 | 4 | .200 | 0 | 64 | 0 | 16 | 0 | 0 | 60.0 | 53 | 22 | 16 | 7 | 22 | 0 | 64 | 2 | 8 | 2.40 | 1.25 | | 2025 | 34 | MLB | NL | CIN | 2 | 2 | .500 | 0 | 40 | 0 | 4 | 0 | 0 | 33.0 | 29 | 15 | 9 | 3 | 19 | 2 | 34 | 2 | 3 | 2.45 | 1.45 | | 2025 | 34 | MLB | NL | CHN | 1 | 0 | 1.000 | 0 | 17 | 0 | 4 | 0 | 0 | 17.2 | 18 | 10 | 10 | 4 | 4 | 0 | 19 | 1 | 1 | 5.09 | 1.25 | | 2025 | 34 | MLB | NL | TOT | 3 | 2 | .600 | 0 | 57 | 0 | 8 | 0 | 0 | 50.2 | 47 | 25 | 19 | 7 | 23 | 2 | 53 | 3 | 4 | 3.38 | 1.38 | | Totals | | | | | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| Minors | Minors | 37 | 29 | .561 | 0 | 99 | 87 | 2 | 6 | 2 | 540.2 | 550 | 244 | 200 | 27 | 140 | 2 | 421 | 24 | 0 | 3.33 | 1.28 | | Career | MIN | 17 | 18 | .486 | 50 | 318 | 0 | 88 | 0 | 0 | 314.2 | 286 | 121 | 110 | 30 | 76 | 15 | 361 | 17 | 31 | 3.15 | 1.15 | | Career | SD | 1 | 5 | .167 | 28 | 42 | 0 | 35 | 0 | 0 | 41.1 | 37 | 22 | 20 | 1 | 9 | 1 | 48 | 8 | 4 | 4.35 | 1.11 | | Career | MIL | 3 | 3 | .500 | 3 | 24 | 0 | 5 | 0 | 0 | 23.0 | 20 | 16 | 14 | 6 | 10 | 1 | 36 | 3 | 1 | 5.48 | 1.30 | | Career | SF | 7 | 8 | .467 | 2 | 124 | 0 | 28 | 0 | 0 | 111.2 | 92 | 49 | 38 | 13 | 47 | 3 | 128 | 5 | 13 | 3.06 | 1.24 | | Career | CIN | 2 | 2 | .500 | 0 | 40 | 0 | 4 | 0 | 0 | 33.0 | 29 | 15 | 9 | 3 | 19 | 2 | 34 | 2 | 3 | 2.45 | 1.45 | | Career | CHN | 1 | 0 | 1.000 | 0 | 17 | 0 | 4 | 0 | 0 | 17.2 | 18 | 10 | 10 | 4 | 4 | 0 | 19 | 1 | 1 | 5.09 | 1.25 | | Career | Majors | 31 | 36 | .463 | 83 | 565 | 0 | 164 | 0 | 0 | 541.1 | 482 | 233 | 201 | 57 | 165 | 22 | 626 | 36 | 53 | 3.34 | 1.20 |
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| Year | Age | Lvl | Lg | Org | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| 2016 | 25 | MLB | AL | MIN | | | | | | | | | | 22.0 | 17 | 8 | 7 | 1 | 6 | 1 | 27 | 1 | 1 | 2.86 | 1.05 | | 2016 | 25 | MLB | AL | MIN | | | | | | | | | | 39.1 | 46 | 21 | 20 | 6 | 10 | 2 | 37 | 4 | 8 | 4.58 | 1.42 | | 2017 | 26 | MLB | AL | MIN | | | | | | | | | | 21.2 | 13 | 6 | 6 | 3 | 6 | 0 | 25 | 2 | 1 | 2.49 | 0.88 | | 2017 | 26 | MLB | AL | MIN | | | | | | | | | | 34.0 | 39 | 14 | 13 | 3 | 15 | 5 | 24 | 1 | 3 | 3.44 | 1.59 | | 2018 | 27 | MLB | AL | MIN | | | | | | | | | | 30.0 | 18 | 6 | 6 | 0 | 8 | 0 | 40 | 1 | 4 | 1.80 | 0.87 | | 2018 | 27 | MLB | AL | MIN | | | | | | | | | | 38.1 | 31 | 14 | 14 | 3 | 8 | 3 | 35 | 1 | 2 | 3.29 | 1.02 | | 2019 | 28 | MLB | AL | MIN | | | | | | | | | | 16.0 | 18 | 4 | 4 | 1 | 4 | 0 | 25 | 2 | 0 | 2.25 | 1.38 | | 2019 | 28 | MLB | AL | MIN | | | | | | | | | | 53.0 | 40 | 16 | 16 | 7 | 7 | 2 | 65 | 4 | 6 | 2.72 | 0.89 | | 2020 | 29 | MLB | AL | MIN | | | | | | | | | | 3.0 | 3 | 2 | 1 | 0 | 1 | 0 | 5 | 0 | 0 | 3.00 | 1.33 | | 2020 | 29 | MLB | AL | MIN | | | | | | | | | | 17.0 | 23 | 12 | 8 | 2 | 3 | 0 | 19 | 1 | 1 | 4.24 | 1.53 | | 2021 | 30 | MLB | AL | MIN | | | | | | | | | | 14.2 | 9 | 6 | 5 | 2 | 1 | 0 | 29 | 0 | 0 | 3.07 | 0.68 | | 2021 | 30 | MLB | AL | MIN | | | | | | | | | | 25.2 | 29 | 12 | 10 | 2 | 7 | 2 | 30 | 0 | 5 | 3.51 | 1.40 | | 2022 | 31 | MLB | | TOT | | | | | | | | | | 17.1 | 10 | 9 | 8 | 0 | 6 | 0 | 26 | 2 | 2 | 4.15 | 0.92 | | 2022 | 31 | MLB | | TOT | | | | | | | | | | 47.0 | 47 | 29 | 26 | 7 | 13 | 2 | 58 | 9 | 3 | 4.98 | 1.28 | | 2023 | 32 | MLB | NL | SF | | | | | | | | | | 28.1 | 9 | 6 | 6 | 0 | 11 | 0 | 39 | 1 | 2 | 1.91 | 0.71 | | 2023 | 32 | MLB | NL | SF | | | | | | | | | | 23.1 | 30 | 21 | 16 | 6 | 14 | 3 | 25 | 2 | 3 | 6.17 | 1.89 | | 2024 | 33 | MLB | NL | SF | | | | | | | | | | 24.1 | 27 | 8 | 6 | 2 | 11 | 0 | 34 | 1 | 5 | 2.22 | 1.56 | | 2024 | 33 | MLB | NL | SF | | | | | | | | | | 35.2 | 26 | 14 | 10 | 5 | 11 | 0 | 30 | 1 | 3 | 2.52 | 1.04 | | 2025 | 34 | MLB | | TOT | | | | | | | | | | 23.2 | 20 | 11 | 8 | 3 | 14 | 0 | 30 | 1 | 0 | 3.04 | 1.44 | | 2025 | 34 | MLB | | TOT | | | | | | | | | | 27.0 | 27 | 14 | 11 | 4 | 9 | 2 | 23 | 2 | 4 | 3.67 | 1.33 | | Totals | | | | | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| Career | vs LH | | | | | | | | | | 201.0 | 144 | 66 | 57 | 12 | 68 | 1 | 280 | 11 | 15 | 2.55 | 1.05 | | Career | vs RH | | | | | | | | | | 340.1 | 338 | 167 | 144 | 45 | 97 | 21 | 346 | 25 | 38 | 3.81 | 1.28 |
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