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| Year | Age | Lvl | Lg | Org | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| 2008 | 19 | R | GCL | BOS | 1 | 4 | .200 | 0 | 10 | 9 | 1 | 0 | 0 | 40.1 | 41 | 18 | 17 | 2 | 21 | 0 | 34 | 0 | 0 | 3.79 | 1.54 | | 2009 | 20 | A- | NYP | BOS | 6 | 4 | .600 | 0 | 13 | 11 | 0 | 0 | 0 | 59.2 | 48 | 22 | 21 | 1 | 25 | 0 | 64 | 2 | 0 | 3.17 | 1.22 | | 2010 | 21 | A | SAL | BOS | 5 | 7 | .417 | 0 | 26 | 24 | 2 | 0 | 0 | 113.2 | 110 | 55 | 47 | 9 | 43 | 0 | 96 | 5 | 0 | 3.72 | 1.35 | | 2011 | 22 | A+ | CAR | BOS | 6 | 11 | .353 | 0 | 26 | 26 | 0 | 0 | 0 | 130.0 | 125 | 84 | 65 | 9 | 53 | 0 | 72 | 13 | 0 | 4.50 | 1.37 | | 2012 | 23 | A+ | CAR | BOS | 5 | 3 | .625 | 0 | 20 | 12 | 4 | 0 | 0 | 76.0 | 86 | 58 | 53 | 9 | 26 | 0 | 61 | 4 | 0 | 6.28 | 1.47 | | 2012 | 23 | AA | EAS | BOS | 2 | 2 | .500 | 0 | 14 | 0 | 7 | 0 | 0 | 27.1 | 23 | 9 | 9 | 2 | 10 | 2 | 21 | 0 | 0 | 2.96 | 1.21 | | 2013 | 24 | MLB | AL | MIN | 3 | 3 | .500 | 0 | 49 | 0 | 18 | 0 | 0 | 76.2 | 71 | 37 | 33 | 5 | 27 | 1 | 49 | 0 | 10 | 3.87 | 1.28 | | 2014 | 25 | AAA | INT | MIN | 1 | 4 | .200 | 6 | 35 | 0 | 19 | 0 | 0 | 60.1 | 55 | 25 | 20 | 1 | 21 | 1 | 63 | 1 | 0 | 2.98 | 1.26 | | 2014 | 25 | MLB | AL | MIN | 2 | 0 | 1.000 | 0 | 25 | 0 | 5 | 0 | 0 | 28.1 | 30 | 10 | 9 | 3 | 8 | 2 | 14 | 1 | 1 | 2.86 | 1.34 | | 2015 | 26 | AAA | INT | MIN | 0 | 2 | .000 | 0 | 7 | 0 | 4 | 0 | 0 | 10.0 | 6 | 7 | 5 | 1 | 6 | 0 | 15 | 0 | 0 | 4.50 | 1.20 | | 2015 | 26 | MLB | AL | MIN | 3 | 2 | .600 | 0 | 27 | 0 | 6 | 0 | 0 | 27.2 | 27 | 9 | 9 | 0 | 12 | 1 | 22 | 0 | 2 | 2.93 | 1.41 | | 2016 | 27 | MLB | AL | MIN | 6 | 7 | .462 | 1 | 72 | 0 | 10 | 0 | 0 | 75.1 | 79 | 34 | 31 | 8 | 23 | 2 | 67 | 2 | 3 | 3.70 | 1.35 | | 2017 | 28 | AAA | INT | | 2 | 0 | 1.000 | 4 | 7 | 0 | 6 | 0 | 0 | 10.0 | 5 | 1 | 1 | 0 | 5 | 0 | 15 | 0 | 0 | 0.90 | 1.00 | | 2017 | 28 | MLB | AL | MIN | 2 | 3 | .400 | 0 | 57 | 0 | 10 | 0 | 0 | 61.1 | 52 | 34 | 32 | 10 | 19 | 5 | 61 | 3 | 7 | 4.70 | 1.16 | | 2018 | 29 | MLB | AL | MIN | 1 | 1 | .500 | 0 | 51 | 0 | 7 | 0 | 0 | 47.2 | 46 | 19 | 18 | 5 | 19 | 1 | 69 | 2 | 2 | 3.40 | 1.36 | | 2018 | 29 | MLB | AL | HOU | 1 | 0 | 1.000 | 2 | 26 | 0 | 4 | 0 | 0 | 23.1 | 11 | 2 | 2 | 1 | 3 | 0 | 32 | 1 | 0 | 0.77 | 0.60 | | 2018 | 29 | MLB | AL | TOT | 2 | 1 | .667 | 2 | 77 | 0 | 11 | 0 | 0 | 71.0 | 57 | 21 | 20 | 6 | 22 | 1 | 101 | 3 | 2 | 2.54 | 1.11 | | 2019 | 30 | AA | TEX | | 0 | 0 | --- | 0 | 1 | 1 | 0 | 0 | 0 | 1.0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0.00 | 1.00 | | 2019 | 30 | MLB | AL | HOU | 2 | 3 | .400 | 3 | 55 | 0 | 8 | 0 | 0 | 54.1 | 37 | 15 | 14 | 6 | 12 | 0 | 72 | 0 | 1 | 2.32 | 0.90 | | 2020 | 31 | MLB | AL | HOU | 1 | 3 | .250 | 12 | 23 | 0 | 15 | 0 | 0 | 21.0 | 21 | 10 | 8 | 2 | 7 | 1 | 29 | 1 | 1 | 3.43 | 1.33 | | 2021 | 32 | MLB | AL | HOU | 5 | 3 | .625 | 26 | 64 | 0 | 49 | 0 | 0 | 64.0 | 49 | 19 | 16 | 4 | 13 | 1 | 81 | 0 | 6 | 2.25 | 0.97 | | 2022 | 33 | MLB | AL | HOU | 3 | 3 | .500 | 33 | 50 | 0 | 43 | 0 | 0 | 48.1 | 30 | 17 | 16 | 4 | 12 | 0 | 65 | 0 | 6 | 2.98 | 0.87 | | 2023 | 34 | MLB | AL | HOU | 4 | 5 | .444 | 31 | 65 | 0 | 56 | 0 | 0 | 65.1 | 54 | 33 | 26 | 8 | 16 | 0 | 74 | 1 | 3 | 3.58 | 1.07 | | 2024 | 35 | MLB | AL | HOU | 2 | 3 | .400 | 4 | 59 | 0 | 8 | 0 | 0 | 56.2 | 58 | 25 | 22 | 4 | 18 | 0 | 58 | 2 | 5 | 3.49 | 1.34 | | Totals | | | | | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| Minors | Minors | 28 | 37 | .431 | 10 | 159 | 83 | 43 | 0 | 0 | 528.1 | 500 | 279 | 238 | 34 | 210 | 3 | 443 | 25 | 0 | 4.05 | 1.34 | | Career | MIN | 17 | 16 | .515 | 1 | 281 | 0 | 56 | 0 | 0 | 317.0 | 305 | 143 | 132 | 31 | 108 | 12 | 282 | 8 | 25 | 3.75 | 1.30 | | Career | HOU | 18 | 20 | .474 | 111 | 342 | 0 | 183 | 0 | 0 | 333.0 | 260 | 121 | 104 | 29 | 81 | 2 | 411 | 5 | 22 | 2.81 | 1.02 | | Career | Majors | 35 | 36 | .493 | 112 | 623 | 0 | 239 | 0 | 0 | 650.0 | 565 | 264 | 236 | 60 | 189 | 14 | 693 | 13 | 47 | 3.27 | 1.16 |
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| Year | Age | Lvl | Lg | Org | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| 2013 | 24 | MLB | AL | MIN | | | | | | | | | | 35.0 | 39 | 20 | 16 | 2 | 14 | 1 | 26 | 0 | 4 | 4.11 | 1.51 | | 2013 | 24 | MLB | AL | MIN | | | | | | | | | | 41.2 | 32 | 17 | 17 | 3 | 13 | 0 | 23 | 0 | 6 | 3.67 | 1.08 | | 2014 | 25 | MLB | AL | MIN | | | | | | | | | | 9.2 | 12 | 6 | 5 | 1 | 5 | 1 | 7 | 1 | 1 | 4.66 | 1.76 | | 2014 | 25 | MLB | AL | MIN | | | | | | | | | | 18.2 | 18 | 4 | 4 | 2 | 3 | 1 | 7 | 0 | 0 | 1.93 | 1.13 | | 2015 | 26 | MLB | AL | MIN | | | | | | | | | | 10.1 | 10 | 3 | 3 | 0 | 3 | 0 | 9 | 0 | 0 | 2.61 | 1.26 | | 2015 | 26 | MLB | AL | MIN | | | | | | | | | | 17.1 | 17 | 6 | 6 | 0 | 9 | 1 | 13 | 0 | 2 | 3.12 | 1.50 | | 2016 | 27 | MLB | AL | MIN | | | | | | | | | | 31.1 | 30 | 11 | 9 | 0 | 18 | 2 | 30 | 0 | 2 | 2.59 | 1.53 | | 2016 | 27 | MLB | AL | MIN | | | | | | | | | | 44.0 | 49 | 23 | 22 | 8 | 5 | 0 | 37 | 2 | 1 | 4.50 | 1.23 | | 2017 | 28 | MLB | AL | MIN | | | | | | | | | | 22.1 | 25 | 16 | 15 | 4 | 11 | 5 | 22 | 1 | 2 | 6.04 | 1.61 | | 2017 | 28 | MLB | AL | MIN | | | | | | | | | | 39.0 | 27 | 18 | 17 | 6 | 8 | 0 | 39 | 2 | 5 | 3.92 | 0.90 | | 2018 | 29 | MLB | | TOT | | | | | | | | | | 28.1 | 17 | 8 | 7 | 2 | 9 | 0 | 44 | 1 | 1 | 2.22 | 0.92 | | 2018 | 29 | MLB | | TOT | | | | | | | | | | 42.2 | 40 | 13 | 13 | 4 | 13 | 1 | 57 | 2 | 1 | 2.74 | 1.24 | | 2019 | 30 | MLB | AL | HOU | | | | | | | | | | 28.1 | 12 | 5 | 5 | 2 | 5 | 0 | 40 | 0 | 0 | 1.59 | 0.60 | | 2019 | 30 | MLB | AL | HOU | | | | | | | | | | 26.0 | 25 | 10 | 9 | 4 | 7 | 0 | 32 | 0 | 1 | 3.12 | 1.23 | | 2020 | 31 | MLB | AL | HOU | | | | | | | | | | 11.1 | 10 | 5 | 4 | 1 | 3 | 1 | 16 | 1 | 0 | 3.18 | 1.15 | | 2020 | 31 | MLB | AL | HOU | | | | | | | | | | 9.2 | 11 | 5 | 4 | 1 | 4 | 0 | 13 | 0 | 1 | 3.72 | 1.55 | | 2021 | 32 | MLB | AL | HOU | | | | | | | | | | 29.0 | 21 | 9 | 7 | 1 | 5 | 1 | 40 | 0 | 1 | 2.17 | 0.90 | | 2021 | 32 | MLB | AL | HOU | | | | | | | | | | 35.0 | 28 | 10 | 9 | 3 | 8 | 0 | 41 | 0 | 5 | 2.31 | 1.03 | | 2022 | 33 | MLB | AL | HOU | | | | | | | | | | 26.1 | 16 | 9 | 8 | 3 | 7 | 0 | 41 | 0 | 3 | 2.73 | 0.87 | | 2022 | 33 | MLB | AL | HOU | | | | | | | | | | 22.0 | 14 | 8 | 8 | 1 | 5 | 0 | 24 | 0 | 3 | 3.27 | 0.86 | | 2023 | 34 | MLB | AL | HOU | | | | | | | | | | 34.0 | 28 | 18 | 13 | 6 | 6 | 0 | 38 | 1 | 1 | 3.44 | 1.00 | | 2023 | 34 | MLB | AL | HOU | | | | | | | | | | 31.1 | 26 | 15 | 13 | 2 | 10 | 0 | 36 | 0 | 2 | 3.73 | 1.15 | | 2024 | 35 | MLB | AL | HOU | | | | | | | | | | 28.0 | 27 | 9 | 8 | 1 | 10 | 0 | 31 | 1 | 4 | 2.57 | 1.32 | | 2024 | 35 | MLB | AL | HOU | | | | | | | | | | 28.2 | 31 | 16 | 14 | 3 | 8 | 0 | 27 | 1 | 1 | 4.40 | 1.36 | | Totals | | | | | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| Career | vs LH | | | | | | | | | | 294.0 | 247 | 119 | 100 | 23 | 96 | 11 | 344 | 6 | 19 | 3.06 | 1.17 | | Career | vs RH | | | | | | | | | | 356.0 | 318 | 145 | 136 | 37 | 93 | 3 | 349 | 7 | 28 | 3.44 | 1.15 |
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