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| Year | Age | Lvl | Lg | Org | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| 2013 | 22 | R | APP | SEA | 1 | 0 | 1.000 | 12 | 15 | 0 | 14 | 0 | 0 | 20.1 | 9 | 0 | 0 | 0 | 5 | 0 | 27 | 1 | 0 | 0.00 | 0.69 | | 2013 | 22 | A- | NWL | SEA | 0 | 1 | .000 | 0 | 5 | 0 | 2 | 0 | 0 | 6.0 | 8 | 4 | 3 | 1 | 1 | 0 | 8 | 0 | 0 | 4.50 | 1.50 | | 2014 | 23 | A | MWL | SEA | 2 | 3 | .400 | 16 | 42 | 0 | 34 | 0 | 0 | 56.0 | 43 | 19 | 18 | 4 | 14 | 1 | 62 | 4 | 0 | 2.89 | 1.02 | | 2015 | 24 | A+ | CAL | SEA | 3 | 8 | .273 | 8 | 42 | 0 | 25 | 0 | 0 | 78.0 | 63 | 29 | 22 | 5 | 27 | 1 | 88 | 5 | 0 | 2.54 | 1.15 | | 2016 | 25 | AA | SOU | SEA | 4 | 1 | .800 | 9 | 18 | 0 | 10 | 0 | 0 | 30.1 | 19 | 4 | 4 | 1 | 11 | 0 | 45 | 1 | 0 | 1.19 | 0.99 | | 2016 | 25 | AAA | PCL | SEA | 1 | 2 | .333 | 1 | 23 | 0 | 3 | 0 | 0 | 34.1 | 28 | 14 | 14 | 6 | 18 | 0 | 39 | 0 | 0 | 3.67 | 1.34 | | 2017 | 26 | AAA | PCL | | 2 | 1 | .667 | 5 | 23 | 0 | 11 | 0 | 0 | 31.1 | 19 | 9 | 9 | 0 | 8 | 0 | 36 | 2 | 0 | 2.59 | 0.86 | | 2017 | 26 | MLB | AL | SEA | 2 | 3 | .400 | 0 | 34 | 0 | 9 | 0 | 0 | 50.1 | 39 | 20 | 18 | 7 | 8 | 0 | 56 | 1 | 2 | 3.22 | 0.93 | | 2018 | 27 | AAA | PCL | | 1 | 0 | 1.000 | 0 | 5 | 0 | 0 | 0 | 0 | 6.0 | 5 | 3 | 2 | 2 | 0 | 0 | 11 | 0 | 0 | 3.00 | 0.83 | | 2018 | 27 | MLB | AL | OAK | 3 | 1 | .750 | 0 | 55 | 0 | 17 | 0 | 0 | 62.0 | 55 | 30 | 30 | 13 | 19 | 1 | 63 | 3 | 1 | 4.35 | 1.19 | | 2019 | 28 | AAA | INT | | 0 | 0 | --- | 2 | 4 | 1 | 2 | 0 | 0 | 6.0 | 2 | 2 | 0 | 0 | 4 | 0 | 10 | 1 | 0 | 0.00 | 1.00 | | 2019 | 28 | MLB | AL | TB | 4 | 2 | .667 | 20 | 66 | 0 | 29 | 0 | 0 | 70.0 | 45 | 19 | 18 | 12 | 13 | 1 | 96 | 1 | 2 | 2.31 | 0.83 | | 2020 | 29 | MLB | NL | SD | 0 | 1 | .000 | 2 | 22 | 0 | 5 | 0 | 0 | 22.0 | 14 | 11 | 11 | 4 | 9 | 0 | 23 | 0 | 2 | 4.50 | 1.05 | | 2021 | 30 | MLB | NL | SD | 4 | 3 | .571 | 0 | 67 | 0 | 10 | 0 | 0 | 63.1 | 56 | 35 | 34 | 16 | 18 | 0 | 69 | 2 | 2 | 4.83 | 1.17 | | 2022 | 31 | MLB | AL | MIN | 4 | 6 | .400 | 9 | 59 | 0 | 27 | 0 | 0 | 63.0 | 60 | 36 | 31 | 12 | 26 | 2 | 84 | 1 | 2 | 4.43 | 1.37 | | 2023 | 32 | MLB | AL | MIN | 5 | 2 | .714 | 1 | 66 | 1 | 15 | 0 | 0 | 69.1 | 45 | 26 | 23 | 5 | 21 | 2 | 65 | 1 | 2 | 2.99 | 0.95 | | 2024 | 33 | MLB | NL | CIN | 4 | 5 | .444 | 1 | 38 | 1 | 5 | 0 | 0 | 38.0 | 40 | 20 | 19 | 6 | 11 | 0 | 44 | 0 | 4 | 4.50 | 1.34 | | Totals | | | | | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| Minors | Minors | 14 | 16 | .467 | 53 | 177 | 1 | 101 | 0 | 0 | 268.1 | 196 | 84 | 72 | 19 | 88 | 2 | 326 | 14 | 0 | 2.41 | 1.06 | | Career | SEA | 2 | 3 | .400 | 0 | 34 | 0 | 9 | 0 | 0 | 50.1 | 39 | 20 | 18 | 7 | 8 | 0 | 56 | 1 | 2 | 3.22 | 0.93 | | Career | OAK | 3 | 1 | .750 | 0 | 55 | 0 | 17 | 0 | 0 | 62.0 | 55 | 30 | 30 | 13 | 19 | 1 | 63 | 3 | 1 | 4.35 | 1.19 | | Career | TB | 4 | 2 | .667 | 20 | 66 | 0 | 29 | 0 | 0 | 70.0 | 45 | 19 | 18 | 12 | 13 | 1 | 96 | 1 | 2 | 2.31 | 0.83 | | Career | SD | 4 | 4 | .500 | 2 | 89 | 0 | 15 | 0 | 0 | 85.1 | 70 | 46 | 45 | 20 | 27 | 0 | 92 | 2 | 4 | 4.75 | 1.14 | | Career | MIN | 9 | 8 | .529 | 10 | 125 | 1 | 42 | 0 | 0 | 132.1 | 105 | 62 | 54 | 17 | 47 | 4 | 149 | 2 | 4 | 3.67 | 1.15 | | Career | CIN | 4 | 5 | .444 | 1 | 38 | 1 | 5 | 0 | 0 | 38.0 | 40 | 20 | 19 | 6 | 11 | 0 | 44 | 0 | 4 | 4.50 | 1.34 | | Career | Majors | 26 | 23 | .531 | 33 | 407 | 2 | 117 | 0 | 0 | 438.0 | 354 | 197 | 184 | 75 | 125 | 6 | 500 | 9 | 17 | 3.78 | 1.09 |
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| Year | Age | Lvl | Lg | Org | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| 2017 | 26 | MLB | AL | SEA | | | | | | | | | | 16.2 | 16 | 9 | 8 | 4 | 3 | 0 | 19 | 0 | 1 | 4.32 | 1.14 | | 2017 | 26 | MLB | AL | SEA | | | | | | | | | | 33.2 | 23 | 11 | 10 | 3 | 5 | 0 | 37 | 1 | 1 | 2.67 | 0.83 | | 2018 | 27 | MLB | AL | OAK | | | | | | | | | | 19.1 | 24 | 11 | 11 | 6 | 11 | 0 | 18 | 0 | 0 | 5.12 | 1.81 | | 2018 | 27 | MLB | AL | OAK | | | | | | | | | | 42.2 | 31 | 19 | 19 | 7 | 8 | 1 | 45 | 3 | 1 | 4.01 | 0.91 | | 2019 | 28 | MLB | AL | TB | | | | | | | | | | 23.1 | 15 | 10 | 10 | 6 | 9 | 1 | 33 | 1 | 0 | 3.86 | 1.03 | | 2019 | 28 | MLB | AL | TB | | | | | | | | | | 46.2 | 30 | 9 | 8 | 6 | 4 | 0 | 63 | 0 | 2 | 1.54 | 0.73 | | 2020 | 29 | MLB | NL | SD | | | | | | | | | | 10.2 | 8 | 6 | 6 | 2 | 5 | 0 | 13 | 0 | 1 | 5.06 | 1.22 | | 2020 | 29 | MLB | NL | SD | | | | | | | | | | 11.1 | 6 | 5 | 5 | 2 | 4 | 0 | 10 | 0 | 1 | 3.97 | 0.88 | | 2021 | 30 | MLB | NL | SD | | | | | | | | | | 28.0 | 22 | 15 | 14 | 7 | 9 | 0 | 33 | 0 | 0 | 4.50 | 1.11 | | 2021 | 30 | MLB | NL | SD | | | | | | | | | | 35.1 | 34 | 20 | 20 | 9 | 9 | 0 | 36 | 2 | 2 | 5.09 | 1.22 | | 2022 | 31 | MLB | AL | MIN | | | | | | | | | | 28.2 | 23 | 13 | 10 | 3 | 9 | 1 | 37 | 1 | 0 | 3.14 | 1.12 | | 2022 | 31 | MLB | AL | MIN | | | | | | | | | | 34.1 | 37 | 23 | 21 | 9 | 17 | 1 | 47 | 0 | 2 | 5.50 | 1.57 | | 2023 | 32 | MLB | AL | MIN | | | | | | | | | | 29.1 | 22 | 18 | 15 | 2 | 11 | 2 | 33 | 0 | 1 | 4.60 | 1.13 | | 2023 | 32 | MLB | AL | MIN | | | | | | | | | | 40.0 | 23 | 8 | 8 | 3 | 10 | 0 | 32 | 1 | 1 | 1.80 | 0.83 | | 2024 | 33 | MLB | NL | CIN | | | | | | | | | | 14.0 | 14 | 12 | 12 | 6 | 8 | 0 | 18 | 0 | 1 | 7.71 | 1.57 | | 2024 | 33 | MLB | NL | CIN | | | | | | | | | | 24.0 | 26 | 8 | 7 | 0 | 3 | 0 | 26 | 0 | 3 | 2.63 | 1.21 | | Totals | | | | | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| Career | vs LH | | | | | | | | | | 170.0 | 144 | 94 | 86 | 36 | 65 | 4 | 204 | 2 | 4 | 4.55 | 1.23 | | Career | vs RH | | | | | | | | | | 268.0 | 210 | 103 | 98 | 39 | 60 | 2 | 296 | 7 | 13 | 3.29 | 1.01 |
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| Year | Age | Lvl | Lg | Org | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| 2017 | 26 | MLB | AL | SEA | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2019 | 28 | MLB | AL | TB | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2021 | 30 | MLB | NL | SD | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | Totals | | | | | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| Career | SEA | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | Career | TB | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | Career | SD | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | Career | Majors | 4 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 |
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| Year | Age | Lvl | Lg | Org | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| 2017 | 26 | MLB | AL | SEA | | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | --- | --- | --- | --- | | 2017 | 26 | MLB | AL | SEA | | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2019 | 28 | MLB | AL | TB | | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | --- | --- | --- | --- | | 2019 | 28 | MLB | AL | TB | | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2021 | 30 | MLB | NL | SD | | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2021 | 30 | MLB | NL | SD | | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | Totals | | | | | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| Career | vs LH | | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | Career | vs RH | | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 |
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