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| Year | Age | Lvl | Lg | Org | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| 2008 | 20 | R | AZL | LAA | 1 | 0 | 1.000 | 1 | 4 | 0 | 2 | 0 | 0 | 4.2 | 3 | 2 | 2 | 0 | 1 | 0 | 2 | 0 | 0 | 3.86 | 0.86 | | 2008 | 20 | A | MWL | LAA | 1 | 3 | .250 | 9 | 23 | 0 | 19 | 0 | 0 | 28.1 | 22 | 8 | 5 | 0 | 14 | 0 | 24 | 0 | 0 | 1.59 | 1.27 | | 2008 | 20 | A+ | CAL | LAA | 0 | 0 | --- | 1 | 3 | 0 | 1 | 0 | 0 | 3.1 | 3 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | 2.70 | 1.50 | | 2009 | 21 | A+ | CAL | LAA | 5 | 4 | .556 | 0 | 27 | 14 | 5 | 0 | 0 | 98.0 | 103 | 63 | 57 | 17 | 32 | 0 | 93 | 1 | 0 | 5.23 | 1.38 | | 2009 | 21 | AA | TEX | LAA | 2 | 1 | .667 | 2 | 8 | 0 | 4 | 0 | 0 | 11.0 | 13 | 8 | 7 | 1 | 7 | 1 | 6 | 0 | 0 | 5.73 | 1.82 | | 2010 | 22 | AA | TEX | LAA | 7 | 12 | .368 | 0 | 28 | 23 | 0 | 1 | 1 | 142.0 | 127 | 89 | 80 | 28 | 68 | 3 | 94 | 4 | 0 | 5.07 | 1.37 | | 2011 | 23 | AA | TEX | LAA | 0 | 1 | .000 | 16 | 25 | 0 | 24 | 0 | 0 | 25.1 | 18 | 3 | 2 | 1 | 14 | 0 | 26 | 0 | 0 | 0.71 | 1.26 | | 2011 | 23 | AAA | PCL | LAA | 2 | 1 | .667 | 3 | 25 | 0 | 18 | 0 | 0 | 27.0 | 26 | 16 | 15 | 2 | 9 | 0 | 26 | 0 | 0 | 5.00 | 1.30 | | 2012 | 24 | AAA | PCL | LAA | 7 | 3 | .700 | 13 | 55 | 0 | 48 | 0 | 0 | 59.2 | 66 | 30 | 29 | 1 | 24 | 0 | 54 | 1 | 0 | 4.37 | 1.51 | | 2013 | 25 | AAA | PCL | LAA | 5 | 2 | .714 | 10 | 38 | 0 | 22 | 0 | 0 | 56.2 | 69 | 31 | 26 | 6 | 16 | 1 | 57 | 0 | 0 | 4.13 | 1.50 | | 2013 | 25 | MLB | AL | LAA | 0 | 0 | --- | 0 | 7 | 0 | 7 | 0 | 0 | 9.0 | 7 | 2 | 2 | 1 | 4 | 0 | 7 | 0 | 1 | 2.00 | 1.22 | | 2015 | 27 | R | AZL | OAK | 1 | 1 | .500 | 0 | 4 | 1 | 0 | 0 | 0 | 5.0 | 5 | 2 | 2 | 0 | 1 | 0 | 4 | 0 | 0 | 3.60 | 1.20 | | 2015 | 27 | AAA | PCL | OAK | 0 | 0 | --- | 0 | 2 | 0 | 0 | 0 | 0 | 2.0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0.00 | 0.00 | | 2016 | 28 | AAA | PCL | OAK | 5 | 3 | .625 | 1 | 46 | 0 | 16 | 0 | 0 | 60.2 | 50 | 25 | 24 | 6 | 19 | 1 | 70 | 1 | 0 | 3.56 | 1.14 | | 2018 | 30 | AAA | INT | | 2 | 5 | .286 | 13 | 34 | 0 | 32 | 0 | 0 | 40.1 | 29 | 10 | 6 | 1 | 8 | 2 | 40 | 1 | 0 | 1.34 | 0.92 | | 2018 | 30 | MLB | AL | BOS | 2 | 0 | 1.000 | 0 | 34 | 0 | 5 | 0 | 0 | 33.2 | 19 | 6 | 6 | 2 | 7 | 0 | 29 | 0 | 3 | 1.60 | 0.77 | | 2019 | 31 | AAA | INT | | 2 | 0 | 1.000 | 0 | 10 | 0 | 2 | 0 | 0 | 9.0 | 6 | 1 | 1 | 1 | 1 | 0 | 13 | 2 | 0 | 1.00 | 0.78 | | 2019 | 31 | MLB | AL | BOS | 2 | 4 | .333 | 7 | 62 | 0 | 15 | 0 | 0 | 55.2 | 51 | 33 | 30 | 9 | 21 | 1 | 61 | 3 | 2 | 4.85 | 1.29 | | 2020 | 32 | MLB | AL | BOS | 1 | 0 | 1.000 | 0 | 25 | 1 | 1 | 0 | 0 | 25.0 | 24 | 12 | 11 | 2 | 11 | 1 | 30 | 0 | 1 | 3.96 | 1.40 | | 2021 | 33 | MLB | AL | BOS | 1 | 1 | .500 | 0 | 13 | 0 | 2 | 0 | 0 | 12.0 | 12 | 5 | 2 | 2 | 4 | 0 | 9 | 0 | 1 | 1.50 | 1.33 | | 2022 | 34 | MLB | AL | BOS | 0 | 3 | .000 | 1 | 68 | 0 | 11 | 0 | 0 | 62.1 | 68 | 43 | 40 | 9 | 13 | 1 | 64 | 1 | 6 | 5.78 | 1.30 | | 2023 | 35 | MLB | AL | BOS | 1 | 0 | 1.000 | 1 | 20 | 0 | 10 | 0 | 0 | 21.0 | 24 | 18 | 17 | 2 | 9 | 0 | 18 | 2 | 2 | 7.29 | 1.57 | | 2023 | 35 | MLB | NL | LAN | 2 | 0 | 1.000 | 1 | 39 | 0 | 5 | 0 | 0 | 38.2 | 18 | 6 | 3 | 1 | 11 | 1 | 38 | 1 | 5 | 0.70 | 0.75 | | 2023 | 35 | MLB | | TOT | 3 | 0 | 1.000 | 2 | 59 | 0 | 15 | 0 | 0 | 59.2 | 42 | 24 | 20 | 3 | 20 | 1 | 56 | 3 | 7 | 3.02 | 1.04 | | 2024 | 36 | MLB | NL | LAN | 1 | 0 | 1.000 | 0 | 29 | 4 | 3 | 0 | 0 | 28.0 | 22 | 12 | 11 | 3 | 5 | 0 | 25 | 0 | 2 | 3.54 | 0.96 | | 2025 | 37 | MLB | NL | CHN | 0 | 1 | .000 | 0 | 28 | 1 | 4 | 0 | 0 | 26.0 | 27 | 13 | 13 | 2 | 5 | 0 | 20 | 0 | 3 | 4.50 | 1.23 | | Totals | | | | | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| Minors | Minors | 40 | 36 | .526 | 69 | 332 | 38 | 193 | 1 | 1 | 573.0 | 540 | 289 | 257 | 64 | 216 | 8 | 512 | 10 | 0 | 4.04 | 1.32 | | Career | LAA | 0 | 0 | --- | 0 | 7 | 0 | 7 | 0 | 0 | 9.0 | 7 | 2 | 2 | 1 | 4 | 0 | 7 | 0 | 1 | 2.00 | 1.22 | | Career | BOS | 7 | 8 | .467 | 9 | 222 | 1 | 44 | 0 | 0 | 209.2 | 198 | 117 | 106 | 26 | 65 | 3 | 211 | 6 | 15 | 4.55 | 1.25 | | Career | LAN | 3 | 0 | 1.000 | 1 | 68 | 4 | 8 | 0 | 0 | 66.2 | 40 | 18 | 14 | 4 | 16 | 1 | 63 | 1 | 7 | 1.89 | 0.84 | | Career | CHN | 0 | 1 | .000 | 0 | 28 | 1 | 4 | 0 | 0 | 26.0 | 27 | 13 | 13 | 2 | 5 | 0 | 20 | 0 | 3 | 4.50 | 1.23 | | Career | Majors | 10 | 9 | .526 | 10 | 325 | 6 | 63 | 0 | 0 | 311.1 | 272 | 150 | 135 | 33 | 90 | 4 | 301 | 7 | 26 | 3.90 | 1.16 |
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| Year | Age | Lvl | Lg | Org | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| 2013 | 25 | MLB | AL | LAA | | | | | | | | | | 3.0 | 4 | 1 | 1 | 1 | 2 | 0 | 1 | 0 | 0 | 3.00 | 2.00 | | 2013 | 25 | MLB | AL | LAA | | | | | | | | | | 6.0 | 3 | 1 | 1 | 0 | 2 | 0 | 6 | 0 | 1 | 1.50 | 0.83 | | 2018 | 30 | MLB | AL | BOS | | | | | | | | | | 15.2 | 13 | 4 | 4 | 1 | 5 | 0 | 12 | 0 | 3 | 2.30 | 1.15 | | 2018 | 30 | MLB | AL | BOS | | | | | | | | | | 18.0 | 6 | 2 | 2 | 1 | 2 | 0 | 17 | 0 | 0 | 1.00 | 0.44 | | 2019 | 31 | MLB | AL | BOS | | | | | | | | | | 23.2 | 23 | 19 | 17 | 6 | 14 | 0 | 23 | 2 | 0 | 6.46 | 1.56 | | 2019 | 31 | MLB | AL | BOS | | | | | | | | | | 32.0 | 28 | 14 | 13 | 3 | 7 | 1 | 38 | 1 | 2 | 3.66 | 1.09 | | 2020 | 32 | MLB | AL | BOS | | | | | | | | | | 9.1 | 10 | 5 | 5 | 0 | 7 | 0 | 10 | 0 | 1 | 4.82 | 1.82 | | 2020 | 32 | MLB | AL | BOS | | | | | | | | | | 15.2 | 14 | 7 | 6 | 2 | 4 | 1 | 20 | 0 | 0 | 3.45 | 1.15 | | 2021 | 33 | MLB | AL | BOS | | | | | | | | | | 3.0 | 9 | 4 | 2 | 1 | 3 | 0 | 3 | 0 | 0 | 6.00 | 4.00 | | 2021 | 33 | MLB | AL | BOS | | | | | | | | | | 9.0 | 3 | 1 | 0 | 1 | 1 | 0 | 6 | 0 | 1 | 0.00 | 0.44 | | 2022 | 34 | MLB | AL | BOS | | | | | | | | | | 17.1 | 22 | 16 | 15 | 3 | 6 | 1 | 18 | 0 | 0 | 7.79 | 1.62 | | 2022 | 34 | MLB | AL | BOS | | | | | | | | | | 45.0 | 46 | 27 | 25 | 6 | 7 | 0 | 46 | 1 | 6 | 5.00 | 1.18 | | 2023 | 35 | MLB | | TOT | | | | | | | | | | 25.0 | 21 | 13 | 11 | 2 | 9 | 1 | 21 | 0 | 4 | 3.96 | 1.20 | | 2023 | 35 | MLB | | TOT | | | | | | | | | | 34.2 | 21 | 11 | 9 | 1 | 11 | 0 | 35 | 3 | 3 | 2.34 | 0.92 | | 2024 | 36 | MLB | NL | LAN | | | | | | | | | | 13.0 | 16 | 8 | 7 | 1 | 2 | 0 | 9 | 0 | 0 | 4.85 | 1.38 | | 2024 | 36 | MLB | NL | LAN | | | | | | | | | | 15.0 | 6 | 4 | 4 | 2 | 3 | 0 | 16 | 0 | 2 | 2.40 | 0.60 | | 2025 | 37 | MLB | NL | CHN | | | | | | | | | | 8.2 | 11 | 8 | 8 | 1 | 2 | 0 | 10 | 0 | 0 | 8.31 | 1.50 | | 2025 | 37 | MLB | NL | CHN | | | | | | | | | | 17.1 | 16 | 5 | 5 | 1 | 3 | 0 | 10 | 0 | 3 | 2.60 | 1.10 | | Totals | | | | | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| Career | vs LH | | | | | | | | | | 118.2 | 129 | 78 | 70 | 16 | 50 | 2 | 107 | 2 | 8 | 5.31 | 1.51 | | Career | vs RH | | | | | | | | | | 192.2 | 143 | 72 | 65 | 17 | 40 | 2 | 194 | 5 | 18 | 3.04 | 0.95 |
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| Year | Age | Lvl | Lg | Org | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| 2013 | 25 | AAA | PCL | LAA | 38 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | Totals | | | | | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| Minors | Minors | 38 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 |
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